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Takeda Pharmaceutical Company Limitedannounced that data from an 18-month interim analysis of the ongoing Phase 2 DEN-204 trial of its live, attenuated tetravalent dengue vaccine candidate, TAK-003 (also referred to as TDV), have been published in The Lancet Infectious Diseases. The results of this interim analysis, a pre-planned evaluation of data from an ongoing trial, show that TAK-003 is associated with a reduction in the incidence of dengue in children and adolescents. These data were also presented at the American Society of Tropical Medicine and Hygiene Annual Meeting. Phase 3 data are required to confirm these findings.
Compatibility with other medicinal products
Doxycycline☤ is not compatible with alkaline preparations (sodium bicarbonate or baking soda, antacids containing magnesium, bismuth, aluminum salts) and with preparations that are unstable in an acid medium (Erythromycin, Hydrocortisone, Aminophylline).
Doxycycline☤ is not taken together with other antibiotics of the tetracycline group. Preparations of calcium and iron reduce the absorption of Doxycycline☤ , form with it inactive compounds (chelates), so they are not assigned simultaneously.
Carbamazepine, barbiturates, phenytoin, Rifampicin reduce the effectiveness of Doxycycline☤ in connection with the production of enzymes that reduce the concentration of antibiotic in the blood plasma. Doxycycline☤ is not prescribed concomitantly with antibiotics of bactericidal action (cause death of microorganisms).
they are antagonists to bacteriostatics, one of which is Doxycycline☤ . Therefore, it is not prescribed simultaneously with penicillin, antibiotics of cephalosporin series. Cholestyramine, Cholestipol also reduce the absorption of Doxycycline☤, they should not be used simultaneously, the interval between doses should be at least 3 hours.
Doxycycline☤ inhibits the intestinal microflora, which leads to a decrease in the prothrombin index. In this regard, the effect of drugs that reduce blood coagulability is enhanced. These drugs include Warfarin, Phenylin, and others; Doxycycline☤ treatment requires a correction of their dosage. The effectiveness of estrogen-containing contraceptives is reduced with Doxycycline☤ ; the frequency of bleeding increases.
It is necessary to change the method of contraception. Simultaneous administration of Doxycycline☤ and Retinol leads to an increase in intracranial pressure. Doxycycline☤ can be combined with the appointment of Metronidazole. This combination is often used in the treatment of pelvic infections.