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Valproic acid was first synthesized in 1882 by Beverly S. Burton as an analogue of valeric acid , found naturally in valerian . [68] Valproic acid is a carboxylic acid , a clear liquid at room temperature. For many decades, its only use was in laboratories as a "metabolically inert" solvent for organic compounds. In 1962, the French researcher Pierre Eymard serendipitously discovered the anticonvulsant properties of valproic acid while using it as a vehicle for a number of other compounds that were being screened for antiseizure activity. He found it prevented pentylenetetrazol -induced convulsions in laboratory rats . [69] It was approved as an antiepileptic drug in 1967 in France and has become the most widely prescribed antiepileptic drug worldwide. [70] Valproic acid has also been used for migraine prophylaxis and bipolar disorder. [71]

On April 8, 1997, after buying the remaining % of Roussel-Uclaf stock in early 1997, [53] Hoechst AG ( US$30 (equivalent to $ in 2017) billion annual revenue) announced the end of its manufacture and sale of Mifegyne ( US$ (equivalent to $ in 2017) million annual revenue) and the transfer of all rights for medical uses of mifepristone outside of the United States to Exelgyn ., a new single-product company immune to antiabortion boycotts, whose CEO was former Roussel-Uclaf CEO Édouard Sakiz. [54] In 1999, Exelgyn won approval of Mifegyne in 11 additional countries, and in 28 more countries over the following decade. [55]

Mesterolone romania

mesterolone romania

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