Masteron in particular may possibly exhibit even worse effects on the negative cholesterol changes it imparts on the human body. This is due to Masteron’s aromatase inhibiting and anti-estrogenic properties, as the reduction of Estrogen levels below normal physiological levels has been demonstrated in studies to impart an even worse impact on cholesterol profiles than when anabolic steroids are administered alone without an aromatase inhibitor. Testosterone in particular has demonstrated in one clinical study to have only a mild impact on HDL cholesterol after a 12 week period where 280mg of Testosterone Enanthate was administered weekly. The cholesterol profiles had later changed for the worse when an aromatase inhibitor was included, which resulted in a significant 25% drop in HDL cholesterol  . This must be remembered by any potential user of Masteron, and Estrogen levels must be closely monitored so as to ensure Masteron does not reduce Estrogen to the point whereby cholesterol profiles are impacted negatively.
GHRP-6 and the Growth Hormone Secretagogue Receptor
GHRPs are not simply surrogates of GHRH, instead GHRP-6 is an artificial activator of a separate newly discovered receptor called Growth Hormone Secretagogue Receptor (GHS-R). Soon Ghrelin was discovered, the endogenous ligand that binds to the GHS-R. Both Ghrelin and all the synthetic compounds such as GHRP-6 were termed “Growth Hormone Secretagogues” (GHSs). One side effect of GHRP-6 is a significant increase in appetite due to stimulating the release of Ghrelin, a peptide that is released naturally in the lining of the stomach that increases hunger and gastric emptying. Also, GHRP-6 causes stimulation of the anterior pituitary gland which causes an increase in Growth Hormone release. The increased amounts of Growth Hormone can cause the liver to secrete the hormone IGF-1, which improves the animal body’s ability to burn fat and build muscle. Since GHRP-6 acts directly on the feedback loop which signals the inhibition of Growth Hormone release, GHRP-6 can re-stimulate the production of Growth Hormone.
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6. Rapid Commun Mass Spectrom. 2008;22(3):321-9. doi: /. Get MORE UNderground knowledge about steroids, bodybuilding drugs and the latest news on the steroid industry. new drugs and drug busts, we will send it all to you... Subscribe to our mailing list and get interesting news and updates directly to your inbox.