Mast cell h e

Mast cell tumors are an uncommon occurrence in horses . They usually occur as benign, solitary masses on the skin of the head, neck, trunk, and legs. Mineralization of the tumor is common. [27] In pigs and cattle , mast cell tumors are rare. They tend to be solitary and benign in pigs and multiple and malignant in cattle. [4] Mast cell tumors are found in the skin of cattle most commonly, but these may be metastases from tumors of the viscera . [28] Other sites in cattle include the spleen, muscle, gastrointestinal tract, omentum , and uterus. [29]

Myeloproliferative Disease
Myeloproliferative diseases are a group of disorders associated with proliferation of one or more distinct cell lines. Patients can experience fatigue, weight loss, abdominal discomfort, easy bruising or bleeding, infections, as well as other symptoms. A specific diagnosis can be based on laboratory studies (. complete blood counts, leukocyte alkaline phosphatase score, polymerase chain reaction assay, serum uric acid level, red blood cell mass) and bone marrow biopsies, which would reflect a change in blood cell counts. Management of the myeloproliferative disease depends on the specific cause. Patients with chronic myelogenous leukemia can be treated with a number of chemotherapeutic agents. In comparison, treatment is targeted at supportive care for patients with polycythemia vera, essential thrombocythemia, and myelofibrosis. Chronic eosinophilic leukemia is characterized by increased eosinophils carrying genetic alterations in blood and bone marrow and is often associated with increased mast cells.

Histamine from enterochromaffin-like cells may well be the primary modulator, but the magnitude of the stimulus appears to result from a complex additive or multiplicative interaction of signals of each type. For example, the low amounts of histamine released constantly from mast cells in the gastric mucosa only weakly stimulate acid secretion, and similarly for low levels of gastrin or acetylcholine. However, when low levels of each are present, acid secretion is strongly forced. Additionally, pharmacologic antagonists of each of these molecules can block acid secretion.

The excess release of mediators can cause clinical features such as pruritus, flushing, nausea, vomiting, diarrhoea, abdominal pain, vascular instability and anaphylaxis. Also, complications may arise when mast cells accumulate in the skin, gastrointestinal tract, bone marrow, liver, spleen, and lymph nodes. [ 2 ] The clinical features of systemic mastocytosis are caused by accumulation of clonally derived mast cells in different tissues, including bone marrow, skin, gastrointestinal tract, liver and spleen. Systemic mastocytosis is now classified as a myeloproliferative neoplasm. [ 3 ]

Mast cell h e

mast cell h e

The excess release of mediators can cause clinical features such as pruritus, flushing, nausea, vomiting, diarrhoea, abdominal pain, vascular instability and anaphylaxis. Also, complications may arise when mast cells accumulate in the skin, gastrointestinal tract, bone marrow, liver, spleen, and lymph nodes. [ 2 ] The clinical features of systemic mastocytosis are caused by accumulation of clonally derived mast cells in different tissues, including bone marrow, skin, gastrointestinal tract, liver and spleen. Systemic mastocytosis is now classified as a myeloproliferative neoplasm. [ 3 ]

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