Alternatively boldenone could be stacked with other non-aromatising drugs such as primobolan (methenolone) or masteron (drostanolone) where the small amount of estrogen produced by boldenone is beneficial and the resultant gains should be lean and more easily kept. Given the long undecylenate ester (11 carbons) normally attached to boldenone, injecting the hormone twice a week is more than sufficient, although favourable for stable blood levels over injecting once per week. If one purely wants to use boldenone for its appetite enhancing properties, lower doses of 400mg/week should suffice for this purpose, although the full benefit of boldenone in my opinion is not achieved at these lower doses. Some example cycles are outlined below (I recommend in all cases 500IUs HCG is administered weekly from week 1 throughout the cycle as this will significantly aid recovery by helping to stop shut-down from fully occurring):
The AR is important for therapeutic target in prostate cancer , thus many different inhibitors have been developed, primarily targeting the ligand binding domain of the protein, while inhibitors that target the N-terminal domain of the protein are still under development.  AR ligands can either be classified based on their structure ( steroidal or nonsteroidal ) or based on their ability to activate or inhibit transcription ( agonists or antagonists ).  Sulforaphane , a phytochemical derived from broccoli or the HSP90 inhibitor ganetespib or the NRF2 activator bardoxolone methyl has been shown to degrade both AR and AR-V7 and thus enhance the efficacy of antagonists like enzalutamide   .