Dibal h reduction

DIBAL is useful in organic synthesis for a variety of reductions, including converting carboxylic acids , their derivatives, and nitriles to aldehydes . DIBAL efficiently reduces α-β unsaturated esters to the corresponding allylic alcohol. [4] By contrast, LiAlH 4 reduces esters and acyl chlorides to primary alcohols , and nitriles to primary amines [use Feiser work-up procedure]. DIBAL reacts slowly with electron-poor compounds, and more quickly with electron-rich compounds. Thus, it is an electrophilic reducing agent whereas LiAlH 4 can be thought of as a nucleophilic reducing agent.

Dibal h reduction

dibal h reduction


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