After the Kefauver Harris Amendment was passed in 1962, the . FDA began the DESI review process to ensure the safety and efficacy of drugs approved under the more lenient pre-1962 standards, including Dianabol.  In 1965, the FDA pressured CIBA to further document its legitimate medical uses, and re-approved the drug for treating post-menopausal osteoporosis and pituitary-deficient dwarfism .  After CIBA's patent exclusivity period lapsed, other manufacturers began to market generic metandienone in the .
As much as there are advantages to using it, there is an equal amount of disadvantages as well. They affect individuals differently. For some people it can cause liver and organ damage. It can also lead to Physchological defects and infertility. Hepatitis B and C are also risk factors when using steroids. Men who take steroids may experience enlarged breasts and females who take it may experience increased facial hair. People who take steroids are also more aggressive than those who don’t. For teenagers taking steroids, the outcome could be devastating. Premature closure of growth cycle is one risk of teenagers taking steroids. These are not long term effects, however, it can be unpleasant nonetheless.
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